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Non-alcoholic hepatosteatosis (NASH) is a serious chronic disease that is becoming increasingly prevalent1;2. Highlighting the interrelated links3 between NASH and other metabolic diseases3, around two thirds1 of those living with type 2 diabetes are believed to also have NASH, and many have obesity as well. NASH is a progressed stage of non-alcoholic fatty liver disease (NAFLD).
At the moment, NASH is without effective pharmacotherapeutic interventions4 and to make matters worse, timely diagnosis of the disease has traditionally been exceedingly difficult due to the lack of non-invasive tests such as blood-based biomarkers. Thus, at clinical debut, people with NASH frequently present2 with wide-spread hepatosteatosis and reduced liver function due to fibrosis or even cirrhosis. Severe outcomes also include liver failure, liver cancer and cardiovascular disease.
Novo Nordisk is heavily invested in improving the diagnosis and treatment of NASH. We have multiple ongoing efforts to identify validated biomarkers and to test potential therapies such as semaglutide (GLP-1 RA) alone or in combination with FGF-21 or other compounds. Working closely with our peers and partners, we also contribute to relevant liver-focused consortia and collaborate with academic groups on translational endeavours.
Thankfully, new advances in the understanding of how to best diagnose and ameliorate NASH are continuously reported. We welcome you to use the NASH area of ScienceHub to stay updated on relevant articles and congresses. Below, we introduce a selection of recent publications and congresses that we invite you to explore, including the accompanying easy-to-approach audio-visual presentations.
Dufour, J-F et al. Endocrine and Metabolic Science 3:10089 (2021)
Brunt, E. et al. Nat Rev Dis Primers 1, 15080 (2015)
Targher, G. et al. Nat Rev Gastroenterol Hepatol 18, 599–612 (2021)
Vuppalanchi, R. et al. Nat Rev Gastroenterol Hepatol 18, 373–392 (2021)