Mim8 enhances procoagulant activity of select hemophilia B-causing factor IX variants
Sebastian Leyes Porello1; Kyumin Lee1; Jacob Lund3; Benjamin Samelson-Jones1,2
MATERIALS AVAILABLE
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Sunday, 22 June 2025
15:30 - 15:45
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OC 20.4
ORAL PRESENTATION
FRONTIER5 direct switch study: Safety of initiating Mim8 prophylaxis without washout of Emicizumab
Johannes Oldenburg1*; Gary Benson2; Pratima Chowdary3; Robert Klamroth4,5; Anne Lienhart6; Davide Matino7; Camila Martins Mazini Tavares8 Keiji Nogami9 Flora Peyvandi10,11; Amalie Rhode Høgh Nielsen8; Guy Young12; Allison P Wheeler13
MATERIALS AVAILABLE
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Monday, 23 June 2025
13:45 - 14:45
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PB0851
POSTER
Non-joint bleeds in patients with hemophilia A or B with inhibitors: Concizumab explorer7 study
Amy Shapiro1;Ana Boban2; Renée Brown Frandsen3; Giancarlo Castaman4; Kingsley Hampton5; Keiji Nogami6; Jameela Sathar7; Senthil Vel3; Jerzy Windyga8; Victor Jimenez Yuste9
MATERIALS AVAILABLE
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13:45 - 14:45
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PB0812
POSTER
Evaluating pen-injector handling and PROs in patients switching from emicizumab to Mim8 in FRONTIER5
In vitro activity of Inno8 in global hemostatic assays alone and with other hemostatic agents.
Jacob Lund1; Kasper Jensen2; Mirella Ezban1
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Tuesday, 24 June 2025
09:45 - 10:00
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OC 51.2
ORAL PRESENTATION
Genomic integration of FVIII transgene in hepatocytes restores durable FVIII activity in vivo
Jacob Lund1; John Moore2; Carsten Dan Ley1; Karl Agger2; Christopher William Smith1; Jesper Tranekær Jørgensen1; Michelle Scalley Kim2; Jazz Hallinan2; Kendall Sanson2; Rikke Hvid Lindecrona1; Lene Diness Jensen1; Nadin Jahnke2; Gert Bolt3; Erin Louise Brown2; Jonas Ahnfelt-Rønne1; Esther Bloem3; Jonas Højfeldt2; Karina Thorn2 and Gro Klitgaard Povlsen1
MATERIALS AVAILABLE
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12:15 - 13:30
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Symposium
Striving towards optimal hemophilia care through patient-centric approaches
Guy Young (USA); Margareth Ozelo (Brazil); Carmen Escuriola Ettingshausen (Germany); Radoslaw Kaczmarek (USA)
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13:45 - 14:45
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PB1423
POSTER
Joint bleed diagnosis and treatment delays in people with hemophilia: Global real-world data
Flora Peyvandi1; Neil Reynolds2; Olivera Rajkovic-Hooley2;Cléa Percier3; Leonardo Gottlob3; Roberta Gualtierotti1
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13:45 - 14:45
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PB1485
POSTER
US physician-reported prophylactic treatment satisfaction and joint health of people with hemophilia
The effect of Concizumab on thrombin generation in FVII deficient plasma
Marianne Kjalke1
MATERIALS AVAILABLE
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15:00 - 15:15
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OC 59.2
ORAL PRESENTATION
Annualized bleeding rates in hemophilia A/B and target joints: Concizumab explorer8 study
Allison P Wheeler1; Pantep Angchaisuksiri2; Shashikant Apte3; Gary Benson4; Renée Brown Frandsen5; Anthony KC Chan6; Hermann Eichler7; Teruhisa Fujii8; Mohamed Salim Nekkal9; Sonata Šaulytė Trakymienė10; Alice Trinchero11; Senthil Vel5 and Jan Astermark12;